New derivatives of imidazole as potential anticancer agents
✍ Scribed by Izabella Krȩżel
- Book ID
- 114019381
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 450 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0014-827X
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract magnified image A series of new imidazole derivatives containing 2(3__H__)‐benzoxazolone or 2(3__H__)‐benzothiazolone ring were synthesized as analogues of the antifungal drug bifonazole. All compounds were tested __in vitro__ against __Candida albicans__, __Candida parapsilosis__, and
The simple anthracycline analogues 3a-e were synthesized as potential anticancer agents. Anodic oxidation of the phenol derivative 4, phthalide anion annelation ofp-quinone monoacetals 5 and selective attachment of the side chain were the three key steps towards these target compounds.