New convenient synthesis of 1,4-benzothiazepines
✍ Scribed by Lajos Fodor; János Szabó; Gábor Bernáth; Pál Sohár
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- French
- Weight
- 171 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
## Abstract As part of an investigation directed to the search of new neurotropic agents we have prepared a number of hydroxy and hydroximino derivatives of the novel thieno and pyrazolo[2,1]benzothiazepine ring systems. Assignments of the __Z__ and __E__ hydroximino isomers were performed by study
The solid phase synthesis of 1,4-benzothiazepin-5-one derivatives, resulting from the reaction of resin-bound protected cysteine with 2-fluoro-5-nitro-benzoic acid followed by a reductive aikylation and an intra molecular cyclization, is described.