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New catalytic route to (E)-β-silyl-α,β-unsaturated ketones

✍ Scribed by Piotr Pawluć


Book ID
113516607
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
417 KB
Volume
23
Category
Article
ISSN
1566-7367

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a-Fluoro-a,b-unsaturated ketones were prepared from trifluoromethyl ketones via a sequence involving Mg metal promoted successive double defluorination. Trifluoromethyl ketones were transformed to b,b-difluoroenol silyl ethers which were then coupled with aldehydes and ketones to b-hydroxy-a,a-diflu