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New boron-containing derivatives of Protohemin IX with antitumor activity

✍ Scribed by V. A. Ol’shevskaya,R. G. Nikitina,A. V. Zaitsev,M. A. Gyul’malieva…

Book ID: 118299009
Publisher: Springer
Year: 2005
Tongue: English
Weight: 105 KB
Volume: 400
Category: Article
ISSN: 0012-5008
DOI: 10.1007/s10631-005-0004-7

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## Abstract Some derivatives of quinazoline and 1, 2‐dihydroquinazoline __N__^3^‐oxide were synthesised and their cytotoxic activities against human leukaemia HL‐60 cells under hypoxic and aerobic conditions were tested and compared to tirapazamine as the reference compound. Compound 8 showed 5‐fol