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New Derivatives of Quinazoline and 1, 2-Dihydroquinazoline N3-Oxide with Expected Antitumor Activity

✍ Scribed by Elżbieta Mikiciuk-Olasik; Katarzyna Baszczak-Światkiewiz; Elżbieta Żurek; Urszula Krajewska; Marek Różalski; Rafał Kruszyński; Tadeusz J. Bartczak

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
117 KB
Volume
337
Category
Article
ISSN
0365-6233

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✦ Synopsis

Abstract

Some derivatives of quinazoline and 1, 2‐dihydroquinazoline N^3^‐oxide were synthesised and their cytotoxic activities against human leukaemia HL‐60 cells under hypoxic and aerobic conditions were tested and compared to tirapazamine as the reference compound. Compound 8 showed 5‐fold higher toxicity under hypoxic conditions than in normal oxygen atmosphere. The structure of quinazoline derivatives was established by X‐ray crystal structure analysis.

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