Synthesis, Antitumor and Antimicrobial Activities of New Peptidyl Derivatives Containing the 1,3-Benzodioxole System.
β Scribed by Ana Cristina Lima Leite; Kezia Peixoto da Silva; Ivone de Souza; Janete Magali de Araujo; Dalci Jose Brondani
- Publisher
- John Wiley and Sons
- Year
- 2005
- Weight
- 25 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0931-7597
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## Abstract Novel metronidazoleβsubstituted 1,2,4βtriazoleβ3βthiole derivatives (III) and (IV) respectively are prepared and tested for their antiparasitic, cytotoxic, antibacterial, and antifungal activity.
Compounds having a-[dihydro-5-substitted 6-thioxo-2H-1.3.5-thiadiazine-3(4H)-yl]benzylpenicillin structure were synthesized by the reaction of ampicilliin trihydrate, formaldehyde and dithiocarbamic acid salts. The smctures were evident from chemical and spectral analysis. The antimicrobial activiti