New approach to the synthesis of deoxynucleoside-phosphoramidite derivatives
β Scribed by Toshiki Tanaka; Sigeru Tamatsukuri; Morio Ikehara
- Publisher
- Elsevier Science
- Year
- 1986
- Tongue
- French
- Weight
- 211 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
The development of a new class of nucleoside phosphites is described. These compounds are stable to normal laboratory conditions, are activated by mild acid treatment, and are observed to react essentially quantitatively with protected nucleosides. A recent, key innovation in oligonucleotide synthes
A simplified procedure for the preparation of deoxynucleoside methyl-and arylphosphoramidites is described. Both types of phosphoramidites can be conveniently activated by N-methylaniline trifluoracetate for their use in oligodeoxynucleotide synthesis.
## Abstract For Abstract see ChemInform Abstract in Full Text.