𝔖 Bobbio Scriptorium
✦   LIBER   ✦

New and Efficient Routes to Biomolecules Substituted with Cyclopentadienyltricarbonylrhenium and -Technetium Derivatives

✍ Scribed by Franck Le Bideau; Michèle Salmain; Siden Top; Gérard Jaouen

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
126 KB
Volume
7
Category
Article
ISSN
0947-6539

No coin nor oath required. For personal study only.

✦ Synopsis

The small, compact, robust, and nonpolar units of [CpM(CO)3] (M = Re, Tc) coupled with biomolecules may be considered as bioorganometallic entities of potential interest in the field of medicinal chemistry. However, the short half-life of useful radionuclides (186Re t1/2 = 3.7 d, 188Re t1/2 = 16.8 h, 99mTc t1/2 = 6 h), the risks inherent in their use, and their cost have led chemists to search for novel synthetic strategies that allow the rapid introduction of the [CpM(CO)3] moiety as a late step in the course of synthesizing the target molecule. The present paper describes different strategies recently reported in the literature to tackle this problem.

📜 SIMILAR VOLUMES

ChemInform Abstract: New and Efficient R
ChemInform Abstract: New and Efficient Routes to Biomolecules Substituted with Cyclopentadienyltricarbonylrhenium and -Technetium Derivatives
✍ Franck Le Bideau; Michele Salmain; Siden Top; Gerard Jaouen 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 25 KB 👁 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

ChemInform Abstract: New and Efficient R
ChemInform Abstract: New and Efficient Routes to CpRe(CO)3 Substituted Steroids.
✍ Franck Le Bideau; El Bachir Kaloum; Pierre Haquette; Ulrich Kernbach; Jerome Mar 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 33 KB 👁 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

A new and efficient route to amino deriv
A new and efficient route to amino derivatives of [1,6]- and [2,7]naphthyridones
✍ Alexei Nemazany; Norbert Haider 📂 Article 📅 1997 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 265 KB

## Abstract Reaction of __N__‐substituted amides of 2‐chloro‐ or 4‐chloronicotinic acid with CH‐acidic nitriles in the presence of a base provides a convenient access to amino derivatives of 1,6‐naphthyrid‐5(6__H__)‐one, compounds of type 4 and 5, or 2,7‐naphthyrid‐1(2__H__)‐one 7.