The 1-substituted ethylidenemalononitriles la-c condensed with triethyl orthoformate in refluxing acetic anhydride to yield the dienes 2a-c. On the other hand, a mixture o f N, N-dimethylformamide and triethyl orthoformate condensed with la-d to yield the N, N-dimethylaminopentadienonitriles 2d-g. T
New routes to polyfunctionally substituted pyridine, pyridopyridine, quinoline, and pyridazine derivatives
β Scribed by Mohamed H. Elnagdi; Ayman W. W. Erian
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 428 KB
- Volume
- 324
- Category
- Article
- ISSN
- 0365-6233
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## Abstract magnified image 3βOxoβ__N__β{4β[(pyrimidinβ2βylamino)sulfonyl]phenyl}butanamide **3** was condensed with (DMFβDMA) in refluxing dry dioxane to yield branched structure **4** not its linear isomeric **5**. Compound **4** readily reacted with active methylene to yield compounds **8aβc, 1
The small, compact, robust, and nonpolar units of [CpM(CO)3] (M = Re, Tc) coupled with biomolecules may be considered as bioorganometallic entities of potential interest in the field of medicinal chemistry. However, the short half-life of useful radionuclides (186Re t1/2 = 3.7 d, 188Re t1/2 = 16.8 h