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New activation of carboxylic acids by reaction with N,N-bis-(2-oxo-3-oxazolidinyl) phosphorodiamidic chloride (ClsPO)

✍ Scribed by Juan Cabré-Castellví; Antonio Luis Palomo-Coll


Book ID
104226001
Publisher
Elsevier Science
Year
1980
Tongue
French
Weight
186 KB
Volume
21
Category
Article
ISSN
0040-4039

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N,N-bis[2-oxo-3-oxazolidinyl]phosphorodi
✍ S.B. Katti; K.L. Agarwal 📂 Article 📅 1985 🏛 Elsevier Science 🌐 French ⚖ 190 KB

Use of a rwel ccupliw reagent, N,N-bi$2-oxo-3-oxazolidinyllphosphorcdiamidic chloride (BUPCC) in the synthesis of oligc&.oxy~-ibonucleotides is described. This reagent allm the synthesis of phosphotriesters in high yields (70-m) without detectable side reactions. Synthesis of a hexanucleotide, d(A-A