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Neuropsychological prediction of recovery in late-onset major depression

✍ Scribed by Teodor Marcos; Maria J. Portella; Victor Navarro; Cristóbal Gastó; Lorena Rami; Luisa Lázaro; Manel Salamero

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
74 KB
Volume
20
Category
Article
ISSN
0885-6230

No coin nor oath required. For personal study only.

✦ Synopsis

Objectives To assess antidepressant response in late-onset major depression in relation to neuropsychological domains: attention, memory and planning. Methods A neuropsychological battery was administered in 30 medication-free patients with late-onset major depression, who were then included in a 12-week antidepressant treatment regimen within a 12-month follow-up period. Logistic regression was used to define a predictive model of recovery. Results Eighteen patients were classed as remitters and seven as non-remitters. The 'indexrem' refers to the results of a logistic regression from verbal learning and planning and had a global predictive power of 84%. Conclusions Our study suggests that the balance between verbal learning (memory) and planning (executive function)both related to the dorsolateral prefrontal cortex-could predicts recovery.

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