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Neuropsychological profiles and short-term outcome in late-onset depression

✍ Scribed by William W. H. Chui; Eric F. C. Cheung; Linda C. W. Lam

Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 136 KB
Volume: 26
Category: Article
ISSN: 0885-6230
DOI: 10.1002/gps.2548

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✦ Synopsis

Neuropsychological impairments are common in older persons with late-onset depression. This study examined the relationship between neuropsychological profiles and short-term outcome in late-onset depression. Methods: A total of 54 non-demented Chinese elders presented with their first major depressive episode after 60 years of age participated in this study and were treated according to a standardised protocol. At entry, they were assessed on neurological signs (Parkinsonian features and neurological soft signs) and neuropsychological measures (executive function, psychomotor-speed, attention and working memory, episodic memory, conceptualisation, construction and global cognitive function). The Hamilton Depression Rating Scale (HAM-D) was administered at baseline, the sixth and 12th week of treatment. Results: Abnormal fist-edge-palm (FEP) test, a sign reflecting impairment in motor sequencing, was more common in non-remitters (defined as HAM-D score above 7) at the 12th week of treatment. Conclusions: The FEP test may be included in the clinical assessment for patients with late-onset depression to identify a susceptible group who may require more intensive treatment. Further research is warranted to ascertain the link between late-onset depression, neuropsychological deficits and prognosis.

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