Objectives To assess antidepressant response in late-onset major depression in relation to neuropsychological domains: attention, memory and planning. Methods A neuropsychological battery was administered in 30 medication-free patients with late-onset major depression, who were then included in a 12
Do levels of dysfunctional attitudes predict recovery in major depression?
✍ Scribed by D. H. Lam; B. Green; M. J. Power; S. Checkley
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 97 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1063-3995
No coin nor oath required. For personal study only.
✦ Synopsis
Thirty-seven patients who fulfilled DSM-lll-R criteria for Major Depressive Disorder were recruited for a double-blind controlled trial of desipramine and placebo for 6 weeks. Initial levels of dysfunctional attitudes in the placebo group, particularly those related to achievement, were found to predict changes in Hamilton Ratings for Depression between the initial Hamilton scores and those at week 6 (Hamilton change scores) with the initial level of depression controlled for. For subjects taking desipramine, levels of dysfunctional attitudes did not predict Hamilton change scores. The findings suggest that dysfunctional attitudes impair spontaneous recovery from depression and that the effects of antidepressant drug treatment may obscure this effect. Recovery from depression may include a complex mixture of biological and psychological pathways.
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