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Neuroprotective effects of riluzole in early phase Parkinson's disease on clinically relevant parameters in the marmoset MPTP model

✍ Scribed by Peternella S. Verhave; Marjan J. Jongsma; Roland M. Van Den Berg; Raymond A.P. Vanwersch; August B. Smit; Ingrid H.C.H.M. Philippens


Book ID
116785884
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
699 KB
Volume
62
Category
Article
ISSN
0028-3908

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This is the first study to investigate the potential protective effects of the lipophilic kavapyrone (+/-)-kavain in the experimental MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) model of Parkinson's disease (PD). Male C57BL/6 mice were treated with (+/-)-kavain (50, 100, or 200 mg/kg i.p.) o