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Neuroprotective effects of rotigotine in the acute MPTP-lesioned mouse model of Parkinson's disease

✍ Scribed by Dieter Scheller; Christine Stichel-Gunkel; Hermann Lübbert; Gregory Porras; Paula Ravenscroft; Michael Hill; Erwan Bezard

Book ID
116770058
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
388 KB
Volume
432
Category
Article
ISSN
0304-3940

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This is the first study to investigate the potential protective effects of the lipophilic kavapyrone (+/-)-kavain in the experimental MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) model of Parkinson's disease (PD). Male C57BL/6 mice were treated with (+/-)-kavain (50, 100, or 200 mg/kg i.p.) o