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Neuroprotective Effect of Curcuminoids Against Inflammation-Mediated Dopaminergic Neurodegeneration in the MPTP Model of Parkinson’s Disease

✍ Scribed by Rudra P. Ojha, Manisha Rastogi, B. Parimala Devi, Aruna Agrawal, G. P. Dubey

Book ID
118814715
Publisher
Springer US
Year
2012
Tongue
English
Weight
548 KB
Volume
7
Category
Article
ISSN
1557-1890

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This is the first study to investigate the potential protective effects of the lipophilic kavapyrone (+/-)-kavain in the experimental MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) model of Parkinson's disease (PD). Male C57BL/6 mice were treated with (+/-)-kavain (50, 100, or 200 mg/kg i.p.) o