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Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease

✍ Scribed by Przedborski, Serge; Liberatore, Gabriel T.; Jackson-Lewis, Vernice; Vukosavic, Slobodanka; Mandir, Allen S.; Vila, Miquel; McAuliffe, W. Geoffrey; Dawson, Valina L.; Dawson, Ted M.

Book ID: 109827276
Publisher: Nature Publishing Group
Year: 1999
Tongue: English
Weight: 578 KB
Volume: 5
Category: Article
ISSN: 1078-8956
DOI: 10.1038/70978

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## Abstract A glial reaction associated with up‐regulation of inflammatory molecules has been suggested to play an important role in dopaminergic neuron loss in Parkinson's disease (PD). Among inflammatory molecules, inducible nitric oxide synthase (iNOS) and cyclooxygenase‐2 (COX‐2) have been focu