Inducible nitric oxide synthase-dependent DNA damage in mouse model of inflammatory bowel disease
β Scribed by Xiaohui Ding; Yusuke Hiraku; Ning Ma; Takuma Kato; Kanako Saito; Masato Nagahama; Reiji Semba; Kagemasa Kuribayashi; Shosuke Kawanishi
- Book ID
- 108583466
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 445 KB
- Volume
- 96
- Category
- Article
- ISSN
- 1347-9032
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Interleukin-8 (IL-8) and nitric oxide (NO) may be important mediators in the pathogenesis of chronic idiopathic inflammatory bowel disease (CIIBD), but their roles in disease activity in ulcerative colitis (UC) and Crohn's disease (CD) are uncertain. The aim of this study was to measure mRNA for IL-
## Background: The diagnosis and classification of inflammatory bowel disease (IBD) require both clinical and histopathologic data. Serum biomarkers would be of considerable benefit to noninvasively monitor the progression of disease, assess effectiveness of therapies, and assist in understanding d
## Nitric oxide (NO) and reactive oxygen species (ROS) are important mediators in the pathogenesis of inflammatory bowel disease (IBD). NO in IBD can be either harmful or protective. NO can react with superoxide anions (O 2 β’ ), yielding the toxic oxidizing agent peroxynitrite (ONOO ). Peroxynitri