𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Neuropharmacological investigations in the stiff-man syndrome

✍ Scribed by H. M. Meinck; B. Conrad

Publisher
Springer
Year
1986
Tongue
English
Weight
770 KB
Volume
233
Category
Article
ISSN
0340-5354

No coin nor oath required. For personal study only.

✦ Synopsis

In a patient with the stiff-man syndrome, abnormal exteroceptive reflexes in hand and arm muscles were used as a tool for investigating the effects of various centrally acting adrenergic drugs by means of acute testing. Clonidine, tizanidine and methamphetamine induced reflex suppression whereas reserpine had a biphasic effect: transient reflex suppression and delayed reflex enhancement. The drug actions on the reflexes paralleled to some degree those on the muscle stiffness. It is concluded that alpha-adrenergic stimulation leads to reflex suppression and muscular relaxation, whereas alpha-adrenergic blockade has the opposite effect. Correspondingly, long-term oral treatment with the alpha-stimulator, tizanidine, proved successful. The hypothesis is put forward that a noradrenergic system which exerts a net inhibitory influence on muscle tone and on exteroceptive reflexes plays an important role in the pathogenesis of the stiff-man syndrome.

πŸ“œ SIMILAR VOLUMES

Stiff-man syndrome in a child
Stiff-man syndrome in a child
✍ Caridad Garzo; Manuel PΓ©rez-Sotelo; Alfredo Traba; Angel Esteban; Dr. Francisco πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 347 KB

broadens the considerable clinical heterogeneity of movement disorders reported in late-onset HD. tromyographic pattern of continuous muscle activity at rest in the affected muscles. Muscle spasms and axial stiffness usually improve with diazepam or baclofen.' Since the initial description of SMS b

Heterogeneity of autoantibodies in stiff
Heterogeneity of autoantibodies in stiff-man syndrome
✍ Dr. Luigi M. E. Grimaldi; Gianvito Martino; Simona Braghi; Angelo Quattrini; Rob πŸ“‚ Article πŸ“… 1993 πŸ› John Wiley and Sons 🌐 English βš– 861 KB
The stiff-man syndrome: Report of a case
The stiff-man syndrome: Report of a case
✍ Fletcher S. Stuart; Margaret Henry; Howard L. Holley πŸ“‚ Article πŸ“… 1960 πŸ› John Wiley and Sons 🌐 English βš– 272 KB πŸ‘ 1 views

## Abstract An additional case of the stiff‐man syndrome manifested by extremely painful, fluctuating muscular spasm and rigidity is reported. Eighteen cases previously reported in the literature are reviewed, and the accumulated indications for a metabolic defect and/or myopathy are presented.