Neuronal and Glial Glycine Transporters Have Different Stoichiometries
✍ Scribed by Michel J. Roux; Stéphane Supplisson
- Book ID
- 117607404
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 302 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0896-6273
No coin nor oath required. For personal study only.
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## Abstract Glial cells possess transport systems for the three major amino acid neurotransmitters glutamate, γ‐aminobutyric acid (GABA) and glycine, involved in the arrest of neurotransmission mediated by these compounds. Two glycine transporters have been cloned: GLYT1, mainly expressed by glial
## Abstract The termination of chemical neurotransmission in the CNS involves the rapid removal of neurotransmitter from synapses by specific transport systems. Such mechanism operates for the three major amino acid neurotransmitters glutamate, γ‐aminobutyric acid (GABA) and glycine. To date, five
## Abstract The termination of chemical neurotransmission in the central nervous system (CNS) involves the rapid removal of neurotransmitter from synapses. This is fulfilled by specific transport systems in neurons and glia, including those for γ‐aminobutyric acid (GABA), the main inhibitory neurot
Two membrane-localized transporter proteins (GLYT1 and GLYT2) are responsible for removal of extracellular glycine in the mammalian CNS. Whereas GLYT1 seems to be expressed mainly in glial cells, GLYT2 is neuronal. The highest concentrations of both transporters are found in glycinergic areas of the