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Glial transporters for glutamate, glycine, and GABA III. Glycine transporters

✍ Scribed by Ana Gadea; Ana María López-Colomé

Book ID
102383394
Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
66 KB
Volume
64
Category
Article
ISSN
0360-4012

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✦ Synopsis

Abstract

Glial cells possess transport systems for the three major amino acid neurotransmitters glutamate, γ‐aminobutyric acid (GABA) and glycine, involved in the arrest of neurotransmission mediated by these compounds. Two glycine transporters have been cloned: GLYT1, mainly expressed by glial cells and shown to colocalize with NMDA receptors, and GLYT2, exclusively expressed by neurons and colocalized with the inhibitory glycine receptors. The way in which the regulation of extracellular glycine concentration by glial glycine transporters affects physiological and pathological conditions is discussed. The presence, differential pharmacology and specific regulation of glycine transporters in glial cells strongly support an important role for glia in the modulation of both, excitatory and inhibitory neurotransmission. J. Neurosci. Res. 64:218–222, 2001. © 2001 Wiley‐Liss, Inc.

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