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Neuromuscular junction destruction during amyotrophic lateral sclerosis: insights from transgenic models

✍ Scribed by Luc Dupuis; Jean-Philippe Loeffler


Book ID
116383738
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
512 KB
Volume
9
Category
Article
ISSN
1471-4892

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## Abstract Microglial activation occurs early during the pathogenesis of amyotrophic lateral sclerosis (ALS). Recent evidence indicates that the expression of mutant Cu^2+^/Zn^2+^ superoxide dismutase 1 (SOD1) in microglia contributes to the late disease progression of ALS. However, the mechanism