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Neuromuscular accumulation of mutant superoxide dismutase 1 aggregates in a transgenic mouse model of familial amyotrophic lateral sclerosis

✍ Scribed by Bradley J. Turner; Elizabeth C. Lopes; Surindar S. Cheema


Book ID
117474232
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
222 KB
Volume
350
Category
Article
ISSN
0304-3940

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Inducible superoxide dismutase 1 aggrega
✍ Bradley J. Turner; Elizabeth C. Lopes; Surindar S. Cheema πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 289 KB

## Abstract High molecular weight detergent‐insoluble complexes of superoxide dismutase 1 (SOD1) enzyme are a biochemical abnormality associated with mutant SOD1‐linked familial amyotrophic lateral sclerosis (FALS). In the present study, SOD1 protein from spinal cords of transgenic FALS mice was fr