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Neuroleptic-induced dopamine hyposensitivity

✍ Scribed by Christopher G. Goetz; Paul M. Carvey; Caroline M. Tanner; Harold L. Klawans


Book ID
118942475
Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
257 KB
Volume
34
Category
Article
ISSN
0024-3205

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Different neuroleptics caused dopamine receptor blockade (antagonism against methylphenidate-induced compulsive gnawing) for varying lengths of time. When the receptor blockade had expired, supersensitivity to dopamine agonists (occurrence of apomorphine-induced compulsive gnawing and enhancement of