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402. Neuroleptic induced dopamine D2 receptor up-regulation in schizophrenia

✍ Scribed by S. Silvestri; J. Schroeder; B. Bubeck; S. Demisch


Book ID
118513113
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
136 KB
Volume
43
Category
Article
ISSN
0006-3223

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The effects of 14 days neuroleptic treatment on the expression of the D3 dopamine receptor gene was investigated in rats using a sensitive polymerase chain reaction assay. In olfactory tubercle, D3 mRNA levels increased following haloperidol (40%), pimozide (56%), and sulpiride (63%) administration,