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Up-regulation of dopamine D2 receptor mRNA in rat striatum by chronic neuroleptic treatment

✍ Scribed by Patrick Rogue; André Hanauer; Jean Zwiller; Anant N. Malviya; Guy Vincendon

Book ID
113398225
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
284 KB
Volume
207
Category
Article
ISSN
0922-4106

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The effects of 14 days neuroleptic treatment on the expression of the D3 dopamine receptor gene was investigated in rats using a sensitive polymerase chain reaction assay. In olfactory tubercle, D3 mRNA levels increased following haloperidol (40%), pimozide (56%), and sulpiride (63%) administration,