Neuroleptic-Induced Supersensitivity and Brain Iron: I. Iron Deficiency and Neuroleptic-Induced Dopamine D2 Receptor Supersensitivity
β Scribed by Dorit Ben-Shachar; Moussa B. H. Youdim
- Book ID
- 111175560
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 596 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0022-3042
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract We studied the in vitro electrical activity of rat neostriatal neurons following chronic neuroleptic treatment. In haloperidolβtreated rats, unlike naive animals, activation of neostriatal D2 dopamine receptors induced a potent presynaptic inhibition of glutamateβmediated excitatory syn
Clozapine and molindone administered to mice for 21 days did not elevate the density of striatal 3H-spiperone binding sites at doses clinically equivalent to 1.5 mg/kg haloperidol, which elevated binding by 29%. Thioridazine (25 mg/kg) elevated binding by 25%. It appears that clinically equivalent d