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Neuroleptic activity of the neuropeptide β-LPH62–77 ([Des-Tyr1]γ-endorphin; DTγE)

✍ Scribed by David De Wied; Gabor L. Kovács; Bela Bohus; Jan M. Van Ree; Henk M. Greven

Book ID
118322916
Publisher
Elsevier Science
Year
1978
Tongue
English
Weight
708 KB
Volume
49
Category
Article
ISSN
0014-2999

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Synthesis of fragments of human β-lipotr
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✍ H. M. Greven; W. A. A. J. Bijl; J. W. van Nispen 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 187 KB

## Abstract The synthesis of the hexadecapeptide des‐1‐tyrosine‐γ‐endorphin, i.e. β‐LPH‐(62‐77), by means of the fragment condensation approach, is described. According to __De Wied__ and co‐workers, this peptide, or a closely related one, may function as an endogenous neuroleptic.

Synthesis of fragments of human β-lipotr
Synthesis of fragments of human β-lipotropin, βh-LPH. Part IV*. The synthesis of shortened peptides related to des-1-tyrosine-γ-endorphin [β-LPH-(62-77)]
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## Abstract The synthesis of several peptides related to β‐LPH‐(62–77) but shortened from the __N__‐terminal end, is described. In these syntheses use has been made of the classical fragment condensation approach.

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(Des-tyr1)-gamma-endorphin (DTγE) in the treatment of depression: Double-blind placebo-controlled trial
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Preliminary evidence of a mood-elevating effect for the endogenous neuropeptide, (des-tyr')-gamma-endorphin, was further investigated in a double-blind placebo-controlled trial over a period of 2 weeks. There were 10 patients in each group. Between-group comparisons on the change in scores by day 14