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(Des-tyr1)-gamma-endorphin (DTγE) in the treatment of depression: Double-blind placebo-controlled trial

✍ Scribed by Rahul Manchanda; Steven Hirsch

Publisher: John Wiley and Sons
Year: 1986
Tongue: English
Weight: 370 KB
Volume: 1
Category: Article
ISSN: 0885-6222
DOI: 10.1002/hup.470010207

No coin nor oath required. For personal study only.

✦ Synopsis

Preliminary evidence of a mood-elevating effect for the endogenous neuropeptide, (des-tyr')-gamma-endorphin, was further investigated in a double-blind placebo-controlled trial over a period of 2 weeks. There were 10 patients in each group. Between-group comparisons on the change in scores by day 14 were non-significant. There was, however, a significant reduction (p = 0.05, two-tailed) of scores on the Montgomery Asberg Depression Rating Scale and the anxious-depression subscale of the BPRS in the endorphin group. It is recommended that the trial be conducted in a larger sample for definitive results.

KEY woRDs-(Des-tyr')-gamma-endorphin, placebo, depression.

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