Neurodevelopment and Schizophrenia

✍ Scribed by Matcheri S. Keshavan (editor), James L. Kennedy (editor), Robin M. Murray (editor)

• Publisher: Cambridge University Press
• Year: 2010
• Tongue: English
• Leaves: 507
• Edition: 1
• Category: Library

✦ Synopsis

Developmental neurobiology has made important strides towards clarifying the pathophysiology of psychiatric disorders over the past decade. Nowhere has the link between basic science and clinical insights become clearer than in the field of schizophrenia research. The contributors to this volume provide a state-of-the-art overview of relevant research, including directions for further investigation. The book will be of interest to researchers in psychiatry and neurobiology, students in psychology, and all mental health practitioners.

✦ Table of Contents

Cover......Page 1
Frontmatter......Page 2
Contents......Page 6
List of contributors......Page 9
Foreword......Page 14
Preface......Page 18
Part I - Basic aspects......Page 20
1 - Genes and brain development......Page 22
2 - Brain development in healthy children and adolescents: magnetic resonance imaging studies......Page 54
3 - Cognitive development: functional magnetic resonance imaging studies......Page 64
4 - Cognitive development in adolescence: cerebral underpinnings, neural trajectories, and the impact of aberrations......Page 88
5 - Brain plasticity and long-term function after early cerebral insult: the example of very preterm birth......Page 108
Part II - Etiological factors......Page 128
6 - Do degenerative changes operate across diagnostic boundaries? The case for glucocorticoid involvement in major psychiatric disorders......Page 130
7 - Velo-cardio-facial syndrome (deletion 22q11.2): a homogeneous neurodevelopmental model for schizophrenia......Page 140
8 - Can structural magnetic resonance imaging provide an alternative phenotype for genetic studies of schizophrenia?......Page 157
9 - Nutritional factors and schizophrenia......Page 175
10 - Schizophrenia, neurodevelopment, and epigenetics......Page 193
11 - Early environmental risk factors for schizophrenia......Page 210
12 - Transcriptomes in schizophrenia: assessing altered gene expression with microarrays......Page 229
13 - Is there a role for social factors in a comprehensive development model for schizophrenia?......Page 243
14 - How does drug abuse interact with familial and developmental factors in the etiology of schizophrenia?......Page 267
Part III - Pathophysiology......Page 290
15 - Developmental dysregulation of the dopamine system and the pathophysiology of schizophrenia......Page 292
16 - The development of "mis-wired" limbic lobe circuitry in schizophrenia and bipolar disorder......Page 314
17 - Development of thalamocortical circuitry and the pathophysiology of schizophrenia......Page 329
18 - X chromosome, estrogen, and brain development: implications for schizophrenia......Page 349
19 - Premorbid structural abnormalities in schizophrenia......Page 366
20 - Neurodegenerative models of schizophrenia......Page 392
21 - Does disordered brain development occur across diagnostic boundaries?......Page 409
Part IV - Clinical implications......Page 432
22 - Can one identify preschizophrenia children?......Page 434
23 - High-risk studies, brain development, and schizophrenia......Page 451
24 - Developmental models and hypothesis-driven early interventions in schizophrenia......Page 474
Index......Page 492