✦ LIBER ✦

Neural Network Prediction of the HIV-1 Protease Cleavage Sites

✍ Scribed by Thomas B. Thompson; Kuo-Chen Chou; Chong Zheng

Publisher: Elsevier Science
Year: 1995
Tongue: English
Weight: 421 KB
Volume: 177
Category: Article
ISSN: 0022-5193
DOI: 10.1006/jtbi.1995.0254

No coin nor oath required. For personal study only.

✦ Synopsis

A back propagation neural network method has been developed to study the pattern of polypeptides that can be cleaved by the HIV-1 protease. This method can incorporate many characteristics of the peptides, such as hydrophobicity, beta-sheet and alpha-helix propensities. Mutations can also be applied to probe the most important factors that influence the cleavage.

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