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ChemInform Abstract: The Active Site of HIV-1 Protease

โœ Scribed by Peter P. Mager


Publisher
John Wiley and Sons
Year
2010
Weight
23 KB
Volume
32
Category
Article
ISSN
0931-7597

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Inhibitors of HIV protease: Unique non-p
โœ Bradley D. Tait; John Domagala; Edmund L. Ellsworth; Donna Ferguson; Christopher ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 405 KB ๐Ÿ‘ 2 views

New templates were designed and prepared which straddle the active site of HIV-1 protease. These templates were designed to be 'flexible scaffolds' upon which substituents could be appended to fill the pockets of HIV protease. The new templates prepared and analysed were 4-hydroxy-5H-furan-2-ones, 4