A back propagation neural network method has been developed to study the pattern of polypeptides that can be cleaved by the HIV-1 protease. This method can incorporate many characteristics of the peptides, such as hydrophobicity, beta-sheet and alpha-helix propensities. Mutations can also be applied
โฆ LIBER โฆ
Stereoselective synthesis of the hydroxyethylene isostere of the HIV protease (Tyr-Pro) cleavage site
โ Scribed by Wayne J. Thompson; Richard G. Ball; Paul L. Darke; Joan A. Zugay; J.E. Thies
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- French
- Weight
- 246 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
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A protocol has been kvelopedjiu rht generation qf hylroxyehyhnine peptide bond isosmes in a poipcr- sqprted synthesis. This has been used to produce the potent HlV-I Protease inhibitor JG345 rqidiy and in good yield. Protease inhibitors have outstanding potential as therapeutic agentst. Recently it