✦ LIBER ✦

Neural activity and immediate early gene expression in the cerebral cortex

✍ Scribed by Kaufmann, Walter E. ;Worley, Paul F.

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 115 KB
Volume: 5
Category: Article
ISSN: 1080-4013
DOI: 10.1002/(sici)1098-2779(1999)5:1<41::aid-mrdd5>3.0.co;2-c

No coin nor oath required. For personal study only.

✦ Synopsis

Immediate early gene (IEG) expression is dynamically regulated in brain neurons, in response to natural activity, and linked to neural plasticity. Because of the demonstrated importance of synaptic activity in neuronal function and development, it is anticipated that IEGs contribute to adult and developmental cortical plasticity. The IEG response includes proteins that function as transcription factors, as well as enzymes and growth factor proteins that can directly modify neuronal and synaptic function. An understanding of the mechanistic contribution of the IEG response to neuronal plasticity will provide information not only about basic developmental processes, and their disturbances in mental retardation, but may also contribute to new diagnostic and therapeutic approaches for these developmental disorders.

1999 Wiley-Liss, Inc.

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