✦ LIBER ✦

Immediate-Early Gene Expression during Regenerative and Mitogen-Induced Liver Growth in the Rat

✍ Scribed by P. R. Holden; J. Odum; A. R. Soames; J. R. Foster; C. R. Elcombe; J. D. Tugwood

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 115 KB
Volume: 12
Category: Article
ISSN: 1095-6670
DOI: 10.1002/(sici)1099-0461(1998)12:2<79::aid-jbt2>3.0.co;2-l

No coin nor oath required. For personal study only.

✦ Synopsis

The nongenotoxic carcinogens phenobarbitone (PB) and methyl clofenapate (MCP) and the hepatomitogen pregnenolone 16␣ carbonitrile (PCN) are direct inducers of hepatic S-phase in rats, whereas the S-phase seen after partial hepatectomy is regenerative. We have investigated S-phase and immediate-early gene expression (c-myc and c-jun) in rat liver following these treatments to study the differences in gene expression associated with direct vs. regenerative responses. Both partial hepatectomy (one-and twothirds) and mitogen treatment caused an increase in hepatic S-phase that peaked around 36 hours. Twothirds partial hepatectomy caused the greatest increase in S-phase followed by one-third partial hepatectomy, then the mitogens PCN, MCP, and PB in that order. This order of response was also seen with c-jun and to a lesser degree with c-myc expression, suggesting that immediate-early gene expression might be linked not only to regenerative S-phase but also to direct mitogeninduced responses.

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