Nerve growth factor regulates the expression of bradykinin binding sites on adult sensory neurons via the neurotrophin receptor p75
โ Scribed by M. Petersen; G. Segond von banchet; B. Heppelmann; M. Koltzenburg
- Book ID
- 117492110
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 645 KB
- Volume
- 83
- Category
- Article
- ISSN
- 0306-4522
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## Abstract We recently isolated mutant PC12 cell clones (PC84 cells) by transfection of PC12 cells with nerve growth factor (NGF) cDNA. These cells secreted active NGF and extended short processes, but proliferated faster than the parental PC12 cells. Because the expression level of p75, a lowโaff
We used compartmented cultures into NGF plus NT3 compartments, while the combinato study the regulation of adult sensory neurite growth tion of BDNF plus NGF resulted in an inhibition of by neurotrophins. We examined the effects of the neuneurite extension compared with NGF alone. We then rotrophins