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Nephrotoxicity of gentamicin and co-trimoxazole combination in rats

✍ Scribed by F.V. Izzettin; B. Ayça; F. Uras; V. Uysal; U. Çevikbaş; T. Yardimci; S.J. Stohs


Book ID
113328531
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
919 KB
Volume
25
Category
Article
ISSN
0306-3623

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✍ R. Marre; N. Tarara; T. Louton; K. Sack 📂 Article 📅 1980 🏛 Springer 🌐 English ⚖ 410 KB

The pharmacokinetics and nephrotoxicity of gentamicin were studied in female Wistar rats of different ages. I.m. administration of 5 mg of gentamicin/kg revealed that young rats (90g) had lower peak serum levels and a prolonged elimination half-life, when compared with adult animals. After repeated