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Increased nephrotoxicity of gentamicin in pyelonephritic rats

✍ Scribed by Beauchamp, Denis; Poirier, André; Bergeron, Michel G

Book ID
109880399
Publisher
Nature Publishing Group
Year
1985
Tongue
English
Weight
873 KB
Volume
28
Category
Article
ISSN
0085-2538

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✍ R. Marre; N. Tarara; T. Louton; K. Sack 📂 Article 📅 1980 🏛 Springer 🌐 English ⚖ 410 KB

The pharmacokinetics and nephrotoxicity of gentamicin were studied in female Wistar rats of different ages. I.m. administration of 5 mg of gentamicin/kg revealed that young rats (90g) had lower peak serum levels and a prolonged elimination half-life, when compared with adult animals. After repeated