Gentamicin nephrotoxicity in cadmium, lead and mercury pretreated rats
β Scribed by C. Viau; A. Bernard; R.R. Lauwerys; P. Tulkens; G. Laurent; P. Maldague
- Publisher
- Elsevier Science
- Year
- 1983
- Tongue
- English
- Weight
- 693 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0300-483X
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π SIMILAR VOLUMES
The pharmacokinetics and nephrotoxicity of gentamicin were studied in female Wistar rats of different ages. I.m. administration of 5 mg of gentamicin/kg revealed that young rats (90g) had lower peak serum levels and a prolonged elimination half-life, when compared with adult animals. After repeated
## Abstract Gentamicin (GM) is used against serious and lifeβthreatening infections, but its use is limited by the occurrence of nephrotoxicity, which involves the generation of free radicals. In this work we tested the effect of a compound with antioxidant properties, tertamethylpyrazine (TMP), a