Effect of osmotic diuresis on gentamicin-induced nephrotoxicity in rats
β Scribed by Robert A. Newman; Leonard B. Weinstock; Dieter W. Gump; Miles P. Hacker; Jerome W. Yates
- Publisher
- Springer-Verlag
- Year
- 1980
- Tongue
- English
- Weight
- 514 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0340-5761
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## Abstract The effect of __Ξ±__βmelanocyte stimulating hormone (__Ξ±__βMSH) was investigated on gentamicinβinduced acute renal injury in rats. SpragueβDawley rats (200β250 g; __n__ = 8β10) were treated with gentamicin sulphate (GEN; 80 mg kg^β1^) or saline intraperitoneally for 7 consecutive days. _
To study the effects of chronic osmotic diuresis which were not associated with hyperglycaemia on the rat kidney, osmotic diuresis was induced byi. v. infusion of urea. A 5 mol/1 urea solution was continuously infused at a rate of 100 ml. kg-1. day-t on the basis of body weight on day 0. Duration of