Protective effects of corn silk extract administration on gentamicin-induced nephrotoxicity in rat
β Scribed by Gholamreza Sepehri; Amin Derakhshanfar; Farnaz Yazdi Zadeh
- Publisher
- Springer-Verlag
- Year
- 2009
- Tongue
- English
- Weight
- 436 KB
- Volume
- 20
- Category
- Article
- ISSN
- 1618-5641
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## Abstract The effect of __Ξ±__βmelanocyte stimulating hormone (__Ξ±__βMSH) was investigated on gentamicinβinduced acute renal injury in rats. SpragueβDawley rats (200β250 g; __n__ = 8β10) were treated with gentamicin sulphate (GEN; 80 mg kg^β1^) or saline intraperitoneally for 7 consecutive days. _
The intraperitoneal administration of gentamicin (100 mg kg[-1] day[-1]) to rats is associated with an increased production of malondialdehyde (MDA), which is an end product of lipid peroxidation in the kidney. The level of glutathione (GSH) and the activity of three antioxidant systems--superoxide