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Neoplastic transformation of rabbit cells by murine sarcoma viruses

✍ Scribed by J. S. Rhim; H. G. Bedigian; R. R. Fox

Publisher
John Wiley and Sons
Year
1982
Tongue
French
Weight
703 KB
Volume
30
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Neoplastic transformation of rabbit cells by Kirsten murine sarcoma virus (Ki‐MSV), the Ki‐MSV pseudotype of baboon endogenous virus (Ki‐MSV[BaEV]) and the Moloney‐MSV pseudotype of feline leukemia virus (M‐MSV[FeLV]) is reported. Rabbit cells can be readily transformed by Ki‐MSV, Ki‐MSV(BaEV) and M‐MSV(FeLV). Rabbit cells transformed by Ki‐MSV and M‐MSV(FeLV) were found to be virus producers, whereas those transformed by Ki‐MSV(BaEV) were nonproducers (NP). The NP cells were obtained by simply infection rabbit cells with Ki‐MSV(BaEV) and subculturing the infected cells. Although the morphologically altered NP cells did not produce infectious virus or murine leukemia virus antigen, they did contain a rescuable MSV genome. All of the transformed cells formed colonies in soft agar, grew to high saturation densities and produced tumors when transplanted into nude mice. The Ki‐MSV and M‐MSV(FeLV)‐transformed cells produced tumors in newborn WH/J rabbits, thus providing an important tool for studying tumor immunity in the rabbit.

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