Neoadjuvant chemotherapy with cisplatin and 5-fluorouracil in advanced squamous cell carcinoma of the head and neck: a randomized Phase III study
✍ Scribed by Freddi Lewin; Lena Damber; Håkan Jonsson; Torsten Andersson; Anne Berthelsen; Anders Biörklund; Erik Blomqvist; Jan F. Evensen; Hanne S. Hansen; Olfred Hansen; Olav Jetlund; Claes Mercke; Hans Modig; Marie Overgaard; Bengt Rosengren; Johan Tausjö; Ulrik Ringborg
- Book ID
- 119521993
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 587 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0167-8140
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Patients with locally advanced, inoperable squamous cell carcinoma of the head and neck were offered three courses of cisplatin and 96-h 5-fluorouracil (5-FU) infusion. Subsequent therapy included surgery when feasible, irradiation therapy, and a maintenance program of methotrexate (MTX)-5-FU. Thirt
## Abstract ## Background. Intraoperative manipulation of the tumor during cancer surgery has long been recognized as a source of metastasis and contamination of the surgical wound during tumor removal. We explored the use of intraoperative chemotherapy to minimize the risk of tumor cell implantat