Cisplatin and 5-fluorouracil chemotherapy in advanced of recurrent squamous cell carcinoma of the head and neck
β Scribed by Sacks, H.G.
- Book ID
- 122515237
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- English
- Weight
- 155 KB
- Volume
- 46
- Category
- Article
- ISSN
- 1531-5053
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Patients with locally advanced, inoperable squamous cell carcinoma of the head and neck were offered three courses of cisplatin and 96-h 5-fluorouracil (5-FU) infusion. Subsequent therapy included surgery when feasible, irradiation therapy, and a maintenance program of methotrexate (MTX)-5-FU. Thirt
## BACKGROUND. The combination of cisplatin and 5-flurouracil (5-FU) is considered standard therapy for patients with recurrent or metastatic squamous cell carcinoma of the head and neck (SCCHN). Paclitaxel has exhibited single-agent activity in patients with this disease. The authors conducted thi
## Abstract ## Background. Intraoperative manipulation of the tumor during cancer surgery has long been recognized as a source of metastasis and contamination of the surgical wound during tumor removal. We explored the use of intraoperative chemotherapy to minimize the risk of tumor cell implantat