Neo-adjuvant chemotherapy with cisplatin and 5-fluorouracil in advanced squamous cell carcinoma of head and neck; a randomiozed phase III study
✍ Scribed by F Lewin; L Damber; H Jonsson; T Anderson; A Berthelsen; A Biörklund; E Bromquist; JF Hansen; O Hasen; O Jedlund; C Merckle; H Modig; M Overgaard; B Rosengren; J Tausjö; U Ringborg
- Book ID
- 117747982
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- French
- Weight
- 132 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1278-3218
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Patients with locally advanced, inoperable squamous cell carcinoma of the head and neck were offered three courses of cisplatin and 96-h 5-fluorouracil (5-FU) infusion. Subsequent therapy included surgery when feasible, irradiation therapy, and a maintenance program of methotrexate (MTX)-5-FU. Thirt
## Abstract ## Background. Intraoperative manipulation of the tumor during cancer surgery has long been recognized as a source of metastasis and contamination of the surgical wound during tumor removal. We explored the use of intraoperative chemotherapy to minimize the risk of tumor cell implantat