Inflammation is progressed by the action of pro-inflammatory cytokines, including IL-1, TNF, IFN-g and IL-6, and is resolved by anti-inflammatory cytokines, such as IL-4, IL-10, IL-13, IFN-a and transforming growth factor-b (TGF-b). Intracellular signal transduction pathways initiated by these cytok
Negative Regulators of Cytokine Signaling
β Scribed by Benjamin T. Kile; Nicos A. Nicola; Warren S. Alexander
- Publisher
- Carden Jennings Publishing
- Year
- 2001
- Tongue
- English
- Weight
- 101 KB
- Volume
- 73
- Category
- Article
- ISSN
- 0925-5710
No coin nor oath required. For personal study only.
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## Abstract The family of Tollβlike receptors (TLRs) expressed by innate immune cells recognizes a spectrum of microbial components as well as molecules released from injured tissues. TLR ligation activates intracellular signaling cascades that culminate in the upβregulation of proinflammatory gene