Negative regulation of cytokine signaling influences inflammation

✍ Scribed by Akihiko Yoshimura; Hiroyuki Mori; Masanobu Ohishi; Daisuke Aki; Toshikatsu Hanada

• Publisher: Elsevier Science
• Year: 2003
• Tongue: English
• Weight: 104 KB
• Volume: 15
• Category: Article
• ISSN: 0952-7915
• DOI: 10.1016/j.coi.2003.09.004

✦ Synopsis

Inflammation is progressed by the action of pro-inflammatory cytokines, including IL-1, TNF, IFN-g and IL-6, and is resolved by anti-inflammatory cytokines, such as IL-4, IL-10, IL-13, IFN-a and transforming growth factor-b (TGF-b). Intracellular signal transduction pathways initiated by these cytokines have been studied extensively; these pathways ultimately activate transcription factors, such as NF-kB, Smad and STATs. Recently, negative feedback regulation of these pathways, mediated by molecules such as A-20, Smad7 and CIS/SOCS family proteins, has been identified. Negative regulation of cytokine signaling is quite important for inflammation.