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Nearest-neighbor and next-nearest-neighbor effects in the proton NMR spectra of the oligoribonucleotides ApGpX and CpApX

✍ Scribed by Jeremy R. Everett; Donald W. Hughes; Russell A. Bell; Dirk Alkema; Thomas Neilson; Paul J. Romaniuk

Publisher
Wiley (John Wiley & Sons)
Year
1980
Tongue
English
Weight
751 KB
Volume
19
Category
Article
ISSN
0006-3525

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✦ Synopsis

Abstract

The variable‐temperature proton nmr spectra of the oligoribonucleotides in the series CpAp__X__ and the series ApGp__X__, X = A, G, C, U, together with the parent dimers CpA and ApG have been measured. A complete analysis of all the nonexchangeable base proton resonances and ribose H‐1′ proton resonances was made. The presence of trends in the shielding abilities of the various bases at both the nearest‐neighbor and next‐nearest‐neighbor positions were identified. The observed shieldings could be used to predict the chemical shifts of protons in related systems. Based on the empirical results from ribodinucleoside monophosphates, the temperature‐dependent behavior of the J~1′2′~ coupling constants of the triribonucleotides suggested that the compounds in the CpAp__X__ series stacked from the 5′‐end to the 3′‐end, while those in the ApGp__X__ series stacked from the 3′‐end to the 5′‐end.

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