Near ultraviolet spectroscopic studies of 2,4-diamino-6-piperidinopyrimidine-3-oxide (minoxidil) and 2,4-diamino-6-piperidinopyrimidine (desoxyminoxidil)
β Scribed by Thomas J. Thamann
- Book ID
- 103906170
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- English
- Weight
- 685 KB
- Volume
- 44
- Category
- Article
- ISSN
- 1386-1425
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## Abstract Minoxidilβ3β²,4β²,;5β²β^3^H(N), 25.6 Ci/mM. has been synthesized by the reaction of piperidineβ3,4,5β^3^H(N) with 2,4βdiaminoβ6βchloroβpyrimidineβ3βoxide. Purification was by paper chromatography. Minoxidil prepared in this way was shown to be suitable for radioimmunoassay and was stable f
## Abstract 2,4βDiaminoβ6β(diallylamino)β__s__βtriazineβ2,4β^14^C was prepared from K^14^CN in a four step sequence of reactions. The product was obtained in 26% yield at a specific activity of 1.01 mCi per mM. This product was converted to the hypotensive agent, 2,4βdiaminoβ6β(diallylamino)β__s__β