NCS-MPP (4-(2′-METHOXY-PHENYL)-1-[2′-(N-2″-PYRIDYL)-P-Isothiocyanobenzamido]-Ethyl-Piperazine): A high affinity and irreversible 5-HT1A receptor ligand
✍ Scribed by Mei-Ping Kung; Mu Mu; Zhi-Ping Zhuang; Hank F. Kung
- Book ID
- 116018870
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 882 KB
- Volume
- 58
- Category
- Article
- ISSN
- 0024-3205
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The in vivo regional distribution and pharmacological profile of a novel iodinated phenylpiperazine derivative, [12311p-MPPI (4-(2'-methoxy-)phenyl-l-[2'-(N-2"pyridinyl)-p-iodobenzamido-Iethyl-piperazine), in the rat brain were evaluated for use as a potential in vivo imaging agent for 5-HTlA recept
## Abstract The radiochemical synthesis of the high affinity, selective sigma receptor ligand, N^1^‐3‐[^18^F]Fluoropropyl‐N^4^‐2‐([3,4‐dichlorophenyl]ethyl)piperazine, is reported. The labeled compound is prepared by fluoride displacement on a bismethanesulfonate salt of the propyl methanesulfonylo